Hua
2,4-Diamino-6-hydroxypyrimidine
Hydroxypyrimidine matū Āhuatanga
| Te rewa | 285-286 °C (dec.) (marama) |
| Kohuatanga | 234.22°C (whakatau tata) |
| kiato | 1.3659 (whakatau tata) |
| taupū huritao | 1.7990 (whakatau tata) |
| pāmahana rokiroki. | Kia mau ki roto i te waahi pouri, te hau koretake, te pāmahana rūma |
| whakarewatanga | DMSO (Paku), Methanol (Paku) |
| pka | 10.61±0.50(I Matapaetia) |
| puka | Paura Tioata Pai |
| tae | Ma ki te kirīmi |
| Tairongo | Maamaa Maamaa |
| Merck | 14,2981 |
| BRN | 125006 |
| InChIKey | SWELIMKTDYHAOY-UHFFFAOYSA-N |
| CAS Raraunga Raraunga Tohutoro | 56-06-4(Tuhinga Raraunga CAS) |
| Tohutoro Matū NIST | 4(1H)-pyrimidinone, 2,6-diamino-(56-06-4) |
| Pūnaha Rehita Matū EPA | 2,6-Diamino-4(1H)-pyrimidinone (56-06-4) |
Hydroxypyrimidine Whakaahuatanga Hua
Ko te 2,4-Diamino-6-hydroxypyrimidine he pūhui matū me te tātai rāpoi C4H6N4O.He puhui pararopi no te whanau pyrimidine.Ko te pūhui he hanganga mowhiti pyrimidine, e rua nga roopu amino (NH2) e hono ana ki te 2-turanga me te 4-turanga, me te roopu hydroxyl (OH) e hono ana ki te 6-turanga.Ko te hanganga matū ka taea te whakaatu hei:Hamoni ||H--C--C--C--N--C--C--NH2 ||oh 2,4-Diamino-6-hydroxypyrimidine he maha nga tono i roto i te umanga rongoa.He takawaenga nui i roto i te whakahiatotanga o te maha o nga raau taero, tae atu ki nga raau taero antiviral me te antitumor.Ka whakamahia ano hoki hei whakaputa i etahi tairitenga nucleotide e whakamahia ana i roto i te rangahau rongoa.
I tua atu i nga tono rongoa, ka whakamahia ano te 2,4-diamino-6-hydroxypyrimidine hei whakauru i roto i nga agrochemicals.He whakauru matua ki te whakahiatotanga o nga kaiwhakatikatika tipu tipu me nga fungicides.He mea tino nui ki te whai i te kawa haumaru tika ina whakamahi i te 2,4-diamino-6-hydroxypyrimidine.I te mea kua whakarōpūtia hei whakapouri matū, me whakahaere ma te tupato, me mau nga taputapu tiaki whaiaro kia kore e pa atu.
Hei whakarāpopototanga, ko te 2,4-diamino-6-hydroxypyrimidine he pūhui pararopi me nga tono i roto i nga mara rongoa me te ahuwhenua.Ko tana hanganga matū e whai hua ana hei takawaenga i roto i te whakahiatotanga o nga rongoa me nga kaiwhakahaere tipu tipu.
Nga korero haumaru
| Waehere morearea | Xi |
| Tauākī mōrearea | 36/37/38 |
| Tauākī Haumaru | 22-24/25-36-26 |
| WGK Tiamana | 3 |
| Tuhipoka morearea | Whakariri |
| TSCA | Ae |
| Waehere HS | 29335995 |
Hydroxypyrimidine Te Whakamahinga me te Kohanga
| Whakaahuatanga | Ko te 2,4-Diamino-6-hydroxypyrimidine (DAHP) he mea whiriwhiri, he aukati motuhake o te GTP cyclohydrolase I, ko te taahiraa whakaheke tere mo te whakahiato pterin de novo.I roto i nga pūtau HUVEC, ko te IC50mo te aukati i te BH4Ko te koiora ko te 0.3 mM.Ka taea te whakamahi i te DAHP ki te aukati tika i te hanga KORE i roto i nga momo pūtau maha. |
| Ngā Āhuatanga matū | Mā Mārō |
| Whakamahinga | Ko te 2,4-Diamino-6-hydroxypyrimidine (DAHP) he mea whiriwhiri, he aukati motuhake o te GTP cyclohydrolase I, ko te taahiraa whakaheke tere mo te whakahiato pterin de novo.I roto i nga pūtau HUVEC, ko te IC50 mo te aukati i te BH4 biosynthesis he 0.3 mM.Ka taea te whakamahi i te DAHP ki te aukati i te hanga KORE i roto i te maha o nga momo pūtau.[Cayman Chemical] |
| Whakamahinga | E tu ana i te timatanga o te riima whakahiato i te whanariki e timata ana me tenei warowaiwa e whitu nga warowaiha ka mutu ki nga waikawa amino kakara phenylalanine, tyrosine, me te tryptophan. |
| Whakamahinga | Ko te 2,4-Diamino-6-hydroxypyrimidine (cas # 56-06-4) he pūhui whai hua ki te whakahiato waro. |
| Nga Tikanga Pure | Ka whakaritea mai i te H2O.[Beilstein 25 III/IV 3642.] |
