Di-tert-butyl dicarbonate

Whakaahuatanga Poto:

Ingoa Hua:Di-tert-butyl dicarbonate

kupu taurite:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride, totoka/wai

CAS:24424-99-5

MF:C10H18O5

MW:218.25

EINECS:246-240-1

Ngā Kāwai Hua:Takawaenga Rongoa;Timata Raw Materials & Intermediates;Amino Acid Derivatives;Organics;N-Protecting Reagents;Biochemistry;Peptide Synthesis;Tiaki & Derivatization Reagents (mo te Synthesis);Reagent Protection (Peptide Synthesis);Reagents for Oligosaccharide Synthesis; Chemisynthe Synthesis; Te raupapa waikawa Boc-Amino; Reagents Miscellaneous;DIBOC;1H-Inden-1-ol;bc0001;24424-99-5

Kōnae Mol:24424-99-5.mol

Tukuna he imeera ki a matou

Taipitopito Hua

Tohu Hua

Di-tert-butyl dicarbonate Nga Ahuatanga matū

Te rewa	23 °C (marama)
Kohuatanga	56-57 °C/0.5 mmHg (marama)
kiato	0.95 g/mL i te 25 °C (marama)
pehanga kohu	3.85Pa i te 25 ℃
taupū huritao	n20/D 1.409(marama)
Fp	99 °F
pāmahana rokiroki.	2-8°C
puka	Tino Whakarewa Tioatariki
tae	Mā
Te Kaha Tauwhāiti	0.950
Wairewa wai	Miscible ki te decalin, toluene, waro tetrachloride, tetrahydrofuran, dioxane, waipiro, acetone, acetonitrile me te dimethylformamide.Kare e taea ki te wai.
Tairongo	Makuku Tairongo
BRN	1911173
InChIKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
RangitakiP	1.87 i te 25 ℃
CAS Raraunga Raraunga Tohutoro	24424-99-5(Tuhinga Raraunga CAS)
Pūnaha Rehita Matū EPA	Te waikawa dicarbonic, bis(1,1-dimethylethyl) hākawa (24424-99-5)

Nga korero haumaru

Waehere morearea	T+,T,F,Xi,F+
Tauākī mōrearea	11-19-26-36/37/38-43-10-40
Tauākī Haumaru	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR	UN 2929 6.1/PG 1
WGK Tiamana	3
RTECS	HT0230000
F	4.4-10-21
Paemahana Aunoa	460 °C
Tuhipoka morearea	He mura ahi/Irritant/Tino paitini
TSCA	Ae
HazardClass	6.1
Roopu Paeke	I
Waehere HS	29209010
Te paitini	LD50 ā-waha i roto i te Rapeti: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Di-tert-butyl dicarbonate Te Whakamahinga Me te Kohanga

Ngā Āhuatanga matū	Ko te Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) he karaehe tae noa ki te ma ki te kowhai tioata, te papatipu totoka, te wai marama ranei.Ka rewa huri noa i te pāmahana rūma (mp=23°C).Kare e pirau i tenei wa, ahakoa he iti ake te pāmahana.Hei tauira, ka purea ma te whakamaarama i raro i te pehanga iti i te mahana ki te 65°C.I te teitei ake o te mahana ka pirau ki te isobutene, te waipiro t-butyl me te hauhā.
Whakamahinga	Ko te Di-tert-butyl dicarbonate (Boc2O) he reagent e whakamahia whanuitia ana mo te whakauru i nga roopu whakamarumaru ki te whakahiato peptide.He mahi nui ki te whakarite i te 6-acetyl-1,2,3,4-tetrahydropyridine ma te tauhohenga ki te 2-piperidone.He roopu whakamarumaru e whakamahia ana i roto i te whakahiato peptide wahanga totoka.
Whakaritenga	Ko te whakaritenga o te Di-tert-butyl dicarbonate e whai ake nei: Ki te wairewa tote konutai monoester i tapirihia te 2g o N, N-dimethylformamide, 1g o te pyridine, 1g o te triethylamine, Te whakamahana ki te -5~0°C, 60g te diphosgene i ata haere. tāpiri maturuturunga iho i roto i te 1.5h ka oti te taapiri, ka whakamahana ki te pāmahana rūma (25°C), ka werohia mo te 2h, ka tukuna te tauhohenga kia tu i muri i te tātari, te horoi i te wairewa pararopi.I whakamarokehia ki te konupora konupora sulfate, ka whakamarokehia te whakarewa i te pehanga hau kia 65~70g te hua masivesivá.I muri i te whakamatao me te whakatioatanga, 57-60g o te di-tert-butyl dicarbonate i riro mai i te 60-63%.
Whakamaramatanga	ChEBI: Ko te Di-tert-butyl dicarbonate he anhydride carboxylic acyclic.E hono ana ki te waikawa dicarbonic.
Tauhohenga	Ko te tauhohenga o nga aniline kua whakakapia ki te Boc2O i te aroaro o te nui stoichiometric o 4-dimethylaminopyridine (DMAP) i roto i te whakarewa inert (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) i te pāmahana rūma ka arahi ki te aryl isocyanates i roto i te tata ine i roto i te 10 tau. min. I tirohia ano te Di-tert-butyl dicarbonate me te 4-(dimethylamino)pyridine.Ko o ratou tauhohenga ki nga amine me nga waipiro
Whakaahuatanga Whanui	Di-tert-butyl dicarbonate (Boc₂O) he reagent e whakamahia ana mo te whakauru i te roopu tiaki Boc ki nga mahi amine.Ka whakamahia ano hei kaihoko whakamaoritanga i etahi tauhohenga waro, ina koa me nga waikawa warohiko, etahi roopu hydroxyl, me nga nitroalkanes tuatahi ranei.
Pūmate	He irritant e whara kino ai te kanohi;Ka raru pea te kiri;Tino paitini ma te inhalation
Te mura me te pahū	He mura ahi
Nga Tikanga Pure	Whakarewa i te hākawa mā te whakamahana ki te ~35o, ka whakamakuku ki roto i te korehau.Ki te IR me NMR ( 1810m 1765 cm-1 , i roto i te CCl4 1.50 singlet) e kii ana he tino poke rawa, katahi ka horoi ki te rahinga rite o te H2O kei roto te waikawa citric kia iti te waikawa o te paparanga wai, kohikohia te paparanga waro ka whakamaroke ki runga i te MgSO4 waikore. ka whakamakuku i roto i te korehau.[Pope et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] KAUPAPA.