Hua
N-Methyl-2-pyrrolidone
Pyrrolidone Chemical Properties
| Te rewa | -24 °C (marama) |
| Kohuatanga | 202 °C (marama) 81-82 °C/10 mmHg (marama) |
| kiato | 1.028 g/mL i te 25 °C (marama) |
| kiato kohu | 3.4 (me te hau) |
| pehanga kohu | 0.29 mm Hg (20 °C) |
| taupū huritao | n20/D 1.479 |
| Fp | 187 °F |
| pāmahana rokiroki. | Rokiroki i te +5°C ki te +30°C. |
| whakarewatanga | waiwaro: micible0.1ML/mL, maamaa, kore tae (10%, v/v) |
| puka | Waiwai |
| pka | -0.41±0.20(I Matapaetia) |
| tae | ≤20(APHA) |
| PH | 8.5-10.0 (100g/l, H2O, 20 ℃) |
| Te kakara | Te kakara amine paku |
| Awhe PH | 7.7 - 8.0 |
| rohe pahū | 1.3-9.5%(V) |
| Wairewa wai | >=10 g/100 mL i te 20 ºC |
| Tairongo | Hygroscopic |
| λmax | 283nm(MeOH)(marama) |
| Merck | 14,6117 |
| BRN | 106420 |
| Pūmautanga: | He pumau, engari ka pirau i runga i te maramatanga.Ka tahuna.Kare e hototahi ki te kaha o te waikura, te waikawa kaha, te whakaiti, te turanga. |
| InChIKey | SECXISVLQFMRJM-UHFFFAOYSA-N |
| RangitakiP | -0.46 i te 25 ℃ |
| CAS Raraunga Raraunga Tohutoro | 872-50-4(Tuhinga Raraunga CAS) |
| Tohutoro Matū NIST | 2-Pyrrolidinone, 1-methyl-(872-50-4) |
| Pūnaha Rehita Matū EPA | N-Methyl-2-pyrrolidone (872-50-4) |
Nga korero haumaru
| Waehere morearea | T, Xi |
| Tauākī mōrearea | 45-65-36/38-36/37/38-61-10-46 |
| Tauākī Haumaru | 41-45-53-62-26 |
| WGK Tiamana | 1 |
| RTECS | UY5790000 |
| F | 3-8-10 |
| Paemahana Aunoa | 518 °F |
| TSCA | Y |
| Waehere HS | 2933199090 |
| Raraunga matū morearea | 872-50-4(Raraunga Raraunga Matū Morearea) |
| Te paitini | LD50 ā-waha i roto i te Rapeti: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg |
Pyrrolidone Te Whakamahinga Me te Whakakotahitanga
| Ngā Āhuatanga matū | Ko te N-Methyl-2-pyrrolidone he wai kore tae ki te kowhai marama marama me te kakara haukinia paku.Ko te N-Methyl-2-pyrrolidone he tino micible ki te wai.He tino wairewa i roto i nga waipiro iti, nga ketone iti, ether, ethyl acetate, chloroform, me te benzene me te ngawari te whakarewa i roto i te waiwaro aliphatic.Ko te N-Methyl-2-pyrrolidone he tino waikore, he matū e mau ana, e kore e kino ki te waro rino me te konumohe, he iti te pirau ki te parahi.He iti te adhesiveness, kaha matū me te waiariki pūmautanga, polarity tiketike, me te pähekeheke iti.He paku paitini tenei hua, a ko tona rohe kukū ki te hau he 100ppm.
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| Whakamahinga |
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| paitini | Oral (mus)LD50:5130 mg/kg;Oral (rat)LD50:3914 mg/kg; Dermal (rbt)LD50:8000 mg/kg. |
| Te Tuku Para | Tirohia nga ture a te kawanatanga, rohe, motu ranei mo te tuku tika.Me mahi te whakakore i runga i nga ture whaimana.Te wai, mehemea e tika ana me nga taputapu horoi. |
| rokiroki | Ko te N-Methyl-2-pyrrolidone he hygroscopic (kohia ake te makuku) engari ka mau i raro i nga tikanga noa.Ka kaha te tauhohenga me nga kaiwhakaora kaha penei i te hauwai hauwai, te waikawa nitric, te waikawa pungatara, me era atu.Me karohia te nui o te puaretanga, te maringi ranei hei tikanga pai.E taunaki ana a Lyondell Chemical Company kia mau nga karapu butyl ina whakamahi ana i te N-Methyl-2-pyrrolidone.Ko te N-Methyl-2-pyrrolidone me penapena ki roto i te rino ma, he rino phenolic-raina, he pahū koranu ranei.Ko te Teflon®1 me te Kalrez®1 kua whakaatuhia he mea tika nga taonga mo te peeke.Tena koa tirohia te MSDS i mua i te whakahaere. |
| Whakaahuatanga | Ko te N-Methyl-2-pyrrolidone he whakarewa aprotic me te maha o nga momo tono: te tukatuka petrochemical, te paninga mata, te tae me te poaka, nga huinga horoi ahumahi me te whare, me nga hanganga ahuwhenua me te rongoa.Ko te nuinga he whakapataritari, engari he maha ano nga keehi o te mate paheketanga i roto i tetahi kamupene hiko iti. |
| Ngā Āhuatanga matū | Ko te N-Methyl-2-pyrrolidone he wai kore tae, he wai kowhai marama ranei me te kakara amine.Ka taea e ia te maha o nga tauhohenga matū ahakoa ka whakaaetia hei whakarewa pumau.He ātete ki te hydrolysis i raro i nga tikanga kore, engari ko te waikawa kaha, ko te maimoatanga turanga ranei ka puta te whakatuwheratanga mowhiti ki te waikawa aminobutyric 4-methyl.Ka taea te whakaheke i te N-Methyl-2-pyrrolidone ki te 1-methyl pyrrolidine me te borohydride.Ko te maimoatanga me nga maaota maota ka hua te hanga amida, he takawaenga ka taea te whakakapi ano, i te maimoatanga me te amyl nitrate ka puta te waikawa.Ka taea te taapiri i nga Olefins ki te waahi 3 ma te maimoatanga i te tuatahi me nga esters oxalic, katahi me nga aldehyes e tika ana (Hort me Anderson 1982). |
| Whakamahinga | Ko te N-Methyl-2-pyrrolidone he whakarewa polar e whakamahia ana i roto i te matū waro me te matū polymer.Ko nga tono tauine nui ko te whakaora me te purenga o te acetylenes, te olefins, me te diolefins, te horoi hau, me te tangohanga kakara mai i nga kai whangai.N-Methyl-2-pyrrolidone he whakarewa ahumahi maha.I tenei wa ka whakaaetia a NMP mo te whakamahi i nga rongoa kararehe kararehe anake.Ko te whakatau i te ahua me te paopaotanga o te NMP i roto i te kiore ka whai waahi ki te mohio ki te paitini o tenei matū o waho ka kitea pea e te tangata i roto i te piki haere o nga moni. |
| Whakamahinga | Te whakarewa mo nga kapia teitei-te wera;te tukatuka petrochemical, i roto i te ahumahi hanga microelectronics, nga waikano me nga poaka, nga puhui horoi ahumahi me te whare;nga hanganga ahuwhenua me te rongoa |
| Whakamahinga | N-Methyl-2-pyrrolidone, he pai mo te spectrophotometry, te chromatography me te ICP-MS rapunga. |
| Whakamaramatanga | ChEBI: He mema o te karaehe o te pyrrolidine-2-ones ko te pyrrolidin-2-one ka whakakapihia te hauwai e piri ana ki te hauota ki te roopu methyl. |
| Nga Tikanga Whakaputa | Ko te N-Methyl-2-pyrrolidone ka hangaia e te hohenga o te buytrolactone me te methylamine (Hawley 1977).Ko etahi atu tukanga ko te whakarite ma te hauwaitanga o nga otinga o te waikawa maleic me te waikawa succinic me te methylamine (Hort me Anderson 1982).Ko nga kaihanga o tenei matū ko Lachat Chemical, Inc, Mequon, Wisconsin me GAF Corporation, Covert City, California. |
| Te (ng) Tohutoro | Nga Reta Tetrahedron, 24, wh.1323, 1983DOI: 10.1016/S0040-4039(00)81646-9 |
| Whakaahuatanga Whanui | Ko te N-Methyl-2-Pyrrolidone (NMP) he kaha, he whakarewa aprotic me te whakarewa teitei, me te iti o te waatea.Ko tenei wai karekau he tae, he koropupu teitei, he uira teitei me te wai pehanga kohu iti ka mau i te kakara rite amine.He teitei te matū me te waiariki a NMP, a, ka uru katoa ki te wai i nga pāmahana katoa.Ka taea e NMP te mahi hei whakarewa tahi me te wai, te waipiro, te glycol ethers, te ketones, me te waiwaro kakara/maota.Ko te NMP ka taea te hangarua ma te whakamarumaru me te ngawari te pirau.Karekau a NMP i kitea i te rarangi Hazardous Air Pollutants (HAPs) o te 1990 Clean Air Act Amendments. |
| Tauhohenga Hau me te Wai | Wairewa ki te wai. |
| Kōtaha Tauhohenga | Ko tenei amine he turanga matū tino ngawari.Ko te N-Methyl-2-pyrrolidone ka whakakore i nga waikawa hei hanga tote me te wai.Ko te nui o te wera e puta mai ana mo ia kamiriona o te amine i roto i te whakakorenga he tino motuhake i te kaha o te amine hei turanga.Ko nga Amine karekau e hototahi ki te isocyanates, te waro haukoe, te peroxides, te phenols (waikawa), te epoxide, anhydride, me te hauwai waikawa.Ko te hauwai hau e mura ana ka hangaia e nga amine me nga mea whakaheke kaha, penei i te hydride. |
| Pūmate | He kino te kiri me te kanohi.Raima pahū-ona 2.2–12.2%. |
| Pūmate Hauora | Ka whakapouritia te ihu me te korokoro te ngohanga o te kohu wera.Ko te horomitanga ka mate te waha me te puku.Ko te pa ki nga kanohi ka whakapataritari.Ko te whakapiri ki te kiri ka puta he ahua ngawari, he pukuriri. |
| Pūmate Ahi | Nga Moorearea Motuhake o nga Hua Weranga: Ka taea te hanga i te waikura hauota ki te ahi. |
| Te mura me te pahū | Kore e mura |
| Te whakamahi ahumahi | 1) Ka whakamahia te N-Methyl-2-pyrrolidone hei whakarewa aprotic dipolar whānui, he pumau me te koretake; 2) mo te tangohanga waiwaro kakara mai i nga hinu whakahinu; 3) mo te tango waro hauhaa i roto i nga kaihanga haukini; 4) hei whakarewa mo nga tauhohenga polymerization me nga polymers; 5) hei kaihoroi peita; 6) mo te hanga pesticide (USEPA 1985). Ko etahi atu whakamahinga kore-ahumahi o N-Methyl-2-pyrrolidone kei runga i ona ahuatanga hei whakarewa wehewehe e tika ana mo nga rangahau matū hiko me te matū tinana (Langan me Salman 1987).Ko nga tono rongoa ka whakamahi i nga taonga o te N-Methyl-2-pyrrolidone hei whakanikoniko mo te whakawhiti tere atu o nga matū i roto i te kiri (Kydoniieus 1987; Barry and Bennett 1987; Akhter and Barry 1987).Kua whakaaetia a N-Methyl-2-pyrrolidone hei whakarewa mo te whakangao i te whakaraeraetanga ki nga taonga takai kai (USDA 1986). |
| Whakapā atu ki te mate pāwera | Ko te N-Methyl-2-pyrrolidone he whakarewa aprotic me te maha o nga momo tono: te tukatuka petrochemical, te paninga mata, te tae me te poaka, nga huinga horoi ahumahi me te whare, me nga hanganga ahuwhenua me te rongoa.Ko te nuinga o te mea he whakapataritari, engari ka pa mai te mate mate mate na te roa o te whakapiri. |
| Kōtaha Haumaru | Te paihana ma te ara whakaroto.He paitini na roto i te horomia me nga huarahi intraperitoneal.He paitini ma te pa ki te kiri.He teratogen whakamatautau.Nga hua whakawhanaunga whakamatautau.Ko nga raraunga rerekee kua korerotia.Ka wera i te wa e pa ana ki te wera, ki te mura o te ahi, ki nga kaiwhakaora kaha ranei.Hei patu i te ahi, whakamahia te pahuka, CO2, matū maroke.Ina whakamahana ki te pirau, ka puta he paowa paitini NOx. |
| Te mate pukupuku | Ko nga kiore i pa ki te kohu N-Methyl-2-pyrrolidone i te 0, 0.04, 0.4 mg / L ranei mo te 6 haora / ra, 5 ra / wiki mo nga tau 2. Ko nga kiore tane i te 0.4 mg / L i whakaatu i te iti o te taimaha o te tinana.Karekau he paheketanga paitini, mate pukupuku ranei i kitea i roto i nga kiore i kitea mo te 2 tau ki te 0.04, 0.4mg/L ranei o N-Methyl-2-pyrrolidone.Na te ara dermal, he roopu o nga kiore 32 i whiwhi i te horopeta tuatahi o te 25mg o N-Methyl-2-pyrrolidone i whai i nga wiki 2 i muri mai i nga tono a te kaiwhakatairanga pukupuku phorbol myristate acetate, e toru nga wa i te wiki, neke atu i te 25 wiki.Ko te Dimethylcarbamoyl chloride me te dimethylbenzanthracene he mana pai.Ahakoa ko te roopu N-Methyl-2-pyrrolidone e toru nga pukupuku kiri, kaore tenei urupare i whakaarohia he mea nui ina whakaritea ki tera o nga mana pai. |
| Te ara metabolic | Ka tukuna ki nga kiore he N-methyl-2- pyrrolidinone (NMP) kua tapaina i runga i te reo irirangi, a ko te huarahi nui o te whakaputanga a te kiore ma te mimi.Ko te metabolite nui, e tohu ana i te 70-75% o te horopeta whakahaere, ko te waikawa 4-(methylamino)butenoic.Ka puta mai pea tenei hua totika kore i te whakakorenga o te wai, ka noho pea he roopu hydroxyl i runga i te metabolite i mua i te waikawa waikawa. |
| Te whakakino | Ko nga kiore tane Sprague-Dawley i tukuna he werohanga intraperitoneal kotahi (45 mg/kg) o te radiolabeled 1 -methyl-2-pyrrolidone.Ko nga taumata plasma o te reo irirangi me te puhui i aro turukihia mo nga haora e ono, a ko nga hua i kii he waahanga tohatoha tere ka whai i te waahanga whakakorenga puhoi.Ko te nui o te tapanga i peia ki roto i te mimi i roto i nga haora 12 me te tata ki te 75% o te horopeta kua tohua.Rua tekau ma wha haora i muri mai i te horopeta, ko te whakaeminga o te whakahekenga (mimi) he 80% o te horopeta.I whakamahia nga momo tapanga mowhiti me te methyl, me nga momo [14C]- me te [3H]-kua tapaina l-methyl-2-pyrrolidone.Ko nga tohu tohu tuatahi i mau tonu i roto i nga haora 6 tuatahi i muri i te horopeta.I muri i nga haora 6, i kitea te ate me nga whekau kei roto i nga kohinga teitei o te radioactivity, tata ki te 2-4% o te horopeta.He iti te reo irirangi i kitea i roto i te ate, i te hau manawa ranei.Ko te chromatography wai kaha o te mimi i whakaatu i te noho o tetahi metabolite nui me te rua iti.Ko te metabolite nui (70-75% o te horopeta radioactive e whakahaeretia ana) i tātarihia e te chromatography-papatipu spectrometry me te chromatography hau-papatipu spectrometry me te whakaaro ko te 3- 5-hydroxy-l-methyl-2-pyrrolidone ranei (Wells 1987). |
| Nga Tikanga Pure | Me whakamaroke te pyrrolidone ma te tango i te wai hei *benzene azeotrope.Te whakamaroke hautanga ki te 10 torr ma roto i te pou 100-cm kua kikii ki nga hiihi karaihe.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] He m 86-88o te hauwai (mai i te EtOH me te Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.] |
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